Name :
KDM5B Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to KDM5B
Tested applications :
WB, IF
Species reactivity :
Human
Alternative names :
KDM5B antibody; CT31 antibody; JARID1B antibody; PLU-1 antibody; PLU1 antibody; PPP1R98 antibody; PUT1 antibody; RBBP2H1A antibody; RBP2-H1 antibody; lysine demethylase 5B antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 784-883 of human KDM5B (NP_006609.3).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000IF 1:50 – 1:200
Background :
Histone demethylase that demethylates ‘Lys-4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ‘Lys-9’ or H3 ‘Lys-27’. Demethylates trimethylated, dimethylated and monomethylated H3 ‘Lys-4’. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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