Name :
MARK2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MARK2 Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue. Positive IP detected in rat brain tissue. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 78 kDa,80 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
ELKL motif kinase 1 antibody; EMK 1 antibody; EMK1 antibody; MARK2 antibody; PAR 1 antibody; PAR1 homolog antibody; Par1b antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MARK2 recombinant protein (Accession Number: BC008771). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200
Background :
MARK2 is also named as EMK1(ELKL motif kinase 1), Par1b and belongs to the CAMK Ser/Thr protein kinase family. Par1b/MARK2 plays a critical role in neuronal polarity in the process of axon specification from multiple candidate neurites using primary cultures of mammalian hippocampal neurons(PMID:20194617). It has 16 isoforms produced by alternative promoter usage and alternative splicing and can exsit as a dimer(PMID:16803889).
References :
Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. Molecular cell. 55(3):436-50. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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