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Name :
Anti-CAPG / AFCP antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Rabbit polyclonal to CAPG / AFCP

Tested applications :
ELISA, WB, IP

Species reactivity :
Human CAPG / AFCP

Alternative names :
capping protein (actin filament) antibody; gelsolin-like antibody; CAPG antibody; AFCP antibody; MCP antibody; actin regulatory protein CAP-G antibody; gelsolin-like capping protein antibody; macrophage capping protein antibody; capping protein (actin filament) antibody; gelsolin-like antibody; Capg antibody; gCap39 antibody; mbh1 antibody; actin regulatory protein CAP-G antibody; actin-capping protein GCAP39 antibody; macrophage-capping protein antibody; myc basic motif homolog 1 antibody; AFCP antibody; HEL-S-66 antibody; mbh1 antibody; gCap39 antibody; MCP antibody

Immunogen :
Human CAPG / AFCP recombinant protein

Isotype :
Rabbit IgG

Preparation :
Produced in rabbits immunized with purified, recombinant Human CAPG / AFCP (rh CAPG / AFCP; AAH14549.1; Met1-Lys348). CAPG / AFCP specific IgG was purified by Human CAPG / AFCP affinity chromatography.

Clonality :
Polyclonal

Formulation :
0.2 μm filtered solution in PBS

Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Applications :
WB: 2-10 μg/mlELISA:0.1-0.2 μg/mLThis antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CAPG / AFCP. The detection limit for Human CAPG / AFCP is IP: 1-4 μg/mg of lysate

Background :
CAPG, also known as actin Regulatory Protein CAPG, is a a member of the gelsolin/villin family. Members of this family are actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, CAPG contributes to the control of actin-based motility in non-muscle cells. CAPG may also play an important role in macrophage function.

References :
Watari A. et al., 2007, Oncogene. 25 (56): 7373-80. De Corte V. et al., 2005, J Cell Sci. 117 (22): 5283-92. Van Impe K. et al., 2003, J Biol Chem. 278 (20): 17945-52.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel